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CD34 Mouse anti-Canine, PE, Clone: 1H6, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559369

Catalog No. BDB559369


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Description

Description

The 1H6 antibody reacts with CD34, an ∽110 kDa glycoprotein on the surface of bone marrow-derived progenitors of hematopoietic and endothelial cells. In the bone marrow, 1-3% of cells are stained with 1H6 mAb; whereas peripheral blood leukocytes are not stained. Immunomagnetic depletion of lineage-committed leukocytes from bone marrow results in about three-fold enrichment of CD34+ cells. CD34+ hematopoietic progenitors may be mobilized to the peripheral blood by treatment with recombinant canine granulocyte colony-stimulating factor and stem-cell factor. Furthermore, CD34 is expressed on some canine leukemias. In the mouse, CD34 is also expressed on high endothelial venules (HEV) of lymph nodes and, in this form, functions as a ligand for L-selectin. CD34 expression on HEV of dog lymph nodes has been demonstrated with polyclonal anti-CD34 antibody.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD34
Monoclonal
0.2mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Dog CD34-IgG2a fusion protein and dog myelomonocytic leukemia ML3
0.1 mg
Cell Biology
Canine
IgG1 κ
Flow Cytometry
1H6
PE
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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