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CD34 Mouse anti-Canine, PE, Clone: 1H6, BD

Catalog No. BDB559369 Shop All BD Biosciences Products
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BDB559369 0.1 mg
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Catalog No. BDB559369 Supplier BD Biosciences Supplier No. 559369
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Description

Mouse Monoclonal Antibody

The 1H6 antibody reacts with CD34, an ∽110 kDa glycoprotein on the surface of bone marrow-derived progenitors of hematopoietic and endothelial cells. In the bone marrow, 1-3% of cells are stained with 1H6 mAb; whereas peripheral blood leukocytes are not stained. Immunomagnetic depletion of lineage-committed leukocytes from bone marrow results in about three-fold enrichment of CD34+ cells. CD34+ hematopoietic progenitors may be mobilized to the peripheral blood by treatment with recombinant canine granulocyte colony-stimulating factor and stem-cell factor. Furthermore, CD34 is expressed on some canine leukemias. In the mouse, CD34 is also expressed on high endothelial venules (HEV) of lymph nodes and, in this form, functions as a ligand for L-selectin. CD34 expression on HEV of dog lymph nodes has been demonstrated with polyclonal anti-CD34 antibody.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD34
Applications Flow Cytometry
Classification Monoclonal
Clone 1H6
Concentration 0.2mg/mL
Conjugate PE
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Dog CD34-IgG2a fusion protein and dog myelomonocytic leukemia ML3
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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