CD357 (GITR) Rat anti-Mouse, Alexa Fluor 647, Clone: DTA-1, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 565151
The DTA-1 monoclonal antibody specifically binds to GITR [Glucocorticoid-induced Tumor necrosis factor (TNF) receptor family-Related], a 66-70-kDa homodimer glycoprotein that is a member of the TNF receptor superfamily and is also known as TNFRSF18 and CD357. As its name implies, GITR expression was first detected in T lymphocytes that had been treated with dexamethasone, a glucocorticoid. In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes. It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells. Activation of T and B lymphocytes upregulates GITR expression. GITR is a costimulatory receptor that plays an important role in Regulatory T (Treg)-cell functions, and a GITR Ligand has been detected on B lymphocytes, macrophages, and dendritic cells. mAb DTA-1 abrogates suppression by Treg cells without affecting their proliferative response, while it is co-stimulatory for T lymphocytes that are not Treg cells.
|Alexa Fluor 647|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|GITR; Gitr; glucocorticoid-induced TNFR-related protein; Tnfrsf18; AITR|
|Mouse CD25+ CD4+ T Cell Line|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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