MilliporeSigma™ anti-CD3e PE-Cy7, Clone: 145-2C11,

Catalog No.	Quantity	Conjugate
MABF1581MI	25 μg	PE-Cyanine7

Catalog No. MABF1581MI Supplier MilliporeSigma™ Supplier No. MABF1581

Description

Armenian Hamster Monoclonal Antibody

Specifically detects CD3e Clone: 145-2C11 in Mouse samples, and it is validated for Flow Cytometry

The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation.

Specifications

• Antigen: CD3e
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 145-2C11
• Conjugate: PE-Cyanine7
• Formulation: Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
• Gene Accession No.: P22646
• Gene Symbols: Cd3e
• Host Species: Armenian Hamster
• Immunogen: Proprietary immunogen
• Purification Method: Purified by size-exclusion chromatography
• Quantity: 25 μg
• Regulatory Status: RUO
• Research Discipline: Inflammation, Immunology
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
• Form: Purified
• Isotype: IgG

For Research Use Only