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CD4 Mouse anti-Human, BB515, Clone: RPA-T4, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564419

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Catalog No. BDB564419


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Description

Description

The RPA-T4 monoclonal antibody specifically binds to CD4, a 59 kDa single-chain transmembrane glycoprotein that is expressed on T-helper/inducer cell populations. CD4 is also expressed on thymocytes subsets and at lower levels on monocytes and macrophages. CD4 functions as a co-receptor in MHC class II-restricted antigen-induced T cell activation and as a receptor for human immunodeficiency viruses (HIV). This antibody binds to the D1 domain (CDR1 and CDR3 epitopes) of the CD4 antigen and reacts with approximately 80% of thymocytes and 45% of peripheral blood lymphocytes. RPA-T4 is capable of blocking HIV-1, gp120, and inhibits syncytium formation.

The antibody was conjugated to BD Horizon™ BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (e.g. 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.

Specifications

Specifications

CD4
RPA-T4
L3T4; T-cell surface antigen T4/Leu-3; W3/25; CD4 antigen (p55)
Affinity Purified
IgG1, κ
RUO
Primary
Human
Flow Cytometry
BB515
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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