CD4 Rat anti-Mouse, Unlabeled, Clone: RM4-4, BD

Catalog No.	Quantity
BDB553053	0.5 mg

Catalog No. BDB553053 Supplier BD Biosciences Supplier No. 553053

Description

Rat Monoclonal Antibody

The RM4-4 antibody reacts with the CD4 (L3T4) differentiation antigen expressed on most thymocytes, a subpopulation of mature T lymphocytes (i.e., MHC class II-restricted T cells, including most T helper cells), and a subset of NK-T cells of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid and B-lymphocyte precursors, intrathymic lymphoid precursors, and a subset of splenic dendritic cells. CD4 is expressed on the plasma membrane of mouse egg cells and is involved in adhesion of the egg to MHC class II-bearing sperm. CD4 is an antigen coreceptor on the T-cell surface which interacts with MHC class II molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck. Purified RM4-4 mAb does not block binding of FITC-conjugated GK1.5 mAb (Cat. No. 557307/553729), H129.19 mAb (Cat. No. 553650/553651), or RM4-5 mAb (Cat. No. 553046/553047) to T cells.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

• Antigen: CD4
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: RM4-4
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Description: L3T4
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Rat
• Immunogen: BALB/c mouse thymocytes
• Purification Method: Affinity Purified
• Quantity: 0.5 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG2b κ

For Research Use Only.