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MilliporeSigma™ anti-CD4 Red Fluor 710, Clone: GK1.5,

Rat Monoclonal Antibody

$153.50 - $272.50

Specifications

Antigen CD4
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Format Purified
Formulation Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MABF1575MI
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MilliporeSigma™
MABF1575
25μg
Each for $153.50
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MABF1576MI
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MilliporeSigma™
MABF1576
100μg
Each for $272.50
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Description

Description

Specifically detects CD4 Clone: GK1.5 in Mouse samples, and it is validated for Flow Cytometry

The GK1.5 antibody reacts with mouse CD4, a 55kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will 'compete' for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.
Specifications

Specifications

CD4
Monoclonal
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Flow Cytometry
IgG2b, κ
P06332
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Inflammation, Immunology
Primary
Purified
GK1.5
Rat
Proprietary immunogen
Cd4
RUO
Purified by size-exclusion chromatography
SDS
Product Certifications

For Research Use Only

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