CD40 Hamster anti-Mouse, Alexa Fluor 647, Clone: HM40-3, BD
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 563638
The HM40-3 antibody reacts with CD40, a 40-50-kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. The CD40 molecule has a central role in B-cell growth and differentiation. Furthermore, interactions of CD40 with its ligand, CD154, are involved in the initiation and effector stages of cell-mediated immune responses. CD40 may be involved in the triggering of NK cells and NK-T cells. Soluble HM40-3 antibody stimulates splenic and peritoneal B cells to proliferate in vitro . This antibody also induces spleen B cells to express the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). HM40-3 mAb has been demonstrated to inhibit the binding of soluble CD154 (gp39, CD40 Ligand) to soluble CD40 and to cell-surface CD40. This hamster mAb to a mouse leukocyte antigen has been observed to cross-react with similar populations of Lewis, Sprague-Dawley, and LOU16 rat leukocytes.
|Alexa Fluor 647|
|Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.|
|Bp50; Tnfrsf5; TNR5; TRAP; CD40L receptor; GP39; HIGM1; IMD3; T-BAM|
|(BALB/c x NZB) F1 Mouse-derived Lymphoma WEHI-231|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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