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CD40 Hamster anti-Mouse, NA/LE, Unlabeled, Clone: HM40-3, BD

Catalog No. BDB553721 Shop All BD Biosciences Products
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BDB553721 0.5 mg
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Description

Hamster Monoclonal Antibody

The HM40-3 antibody reacts with CD40, a 40-50kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. The CD40 molecule has a central role in B-cell growth and differentiation. Furthermore, interactions of CD40 with its ligand, CD154, are involved in the initiation and effector stages of cell-mediated immune responses. CD40 may be involved in the triggering of NK cells and NK-T cells. Soluble HM40-3 antibody stimulates splenic and peritoneal B cells to proliferate in vitro. This antibody also induces spleen B cells to express the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). HM40-3 mAb has been demonstrated to inhibit the binding of soluble CD154 (gp39, CD40 Ligand) to soluble CD40 and to cell-surface CD40. This hamster mAb to a mouse leukocyte antigen has been observed to cross-react with similar populations of Lewis, Sprague-Dawley, and LOU16 rat leukocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD40
Applications Flow Cytometry
Classification Monoclonal
Clone HM40-3
Concentration 1.0mg/mL
Conjugate Unconjugated
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm filtered. Endotoxin level is ≤0.01 ng/μg of protein.
Host Species Hamster
Immunogen (BALB/c x NZB)F1 mouse-derived lymphoma WEHI-231
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse, Rat
Content And Storage Store undiluted at 4°C
Isotype IgM κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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