CD41 Mouse anti-Human, Non-human primate, Clone: HIP8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119381
This antibody reacts with alpha (a) subunit of CD41 (heavy chain; 120 kDa). This antibody blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation.CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.
|PBS with 15mM sodium azide; pH 7.4|
|BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, GPalpha IIb, integrin alpha-IIb, platelet fibrinogen receptor, alpha subunit, platelet membrane glycoprotein IIb, platelet-specific antigen BAK, ITGA2B|
|4° C, do not freeze|
|Flow Cytometry, Immunohistochemistry (Frozen)|
|Human, Non-human Primate|
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