CD41b Mouse anti-Human, Unlabeled, Clone: HIP2, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 555468

Catalog No. BDB555468

Description

The HIP2 monoclonal antibody specifically binds to CD41b. CD41b/CD41 is encoded by the ITGA2B gene and is also known as Platelet glycoprotein GPIIb and Integrin alpha IIb. CD41 is transmembrane glycoprotein that is post-translationally processed into a disulfide linked α-chain and β-chain. CD41 combines with CD61, otherwise known as Glycoprotein IIIa or β3 integrin, to form the CD41/CD61 (GPIIb/IIIa) complex. This complex is expressed on platelets and megakaryocytes and is involved in platelet activation, aggregation and binding to extracellular matrix proteins. Upon platelet activation, the CD41/CD61 complex can function as a receptor for fribrinogen, fibronectin and von Willebrand factor. In contrast to other CD41b antibodies, HIP2 does not detect anti-ZWa bound to GPIIb/IIIa. This antibody appears to be a weak aggregation inducer.

Specifications

• Antigen: CD41b
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: ITGA2B; CD41; GP2B; GPIIb; GPalpha IIb; Platelet glycoprotein GPIIb
• Host Species: Mouse
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG3 κ

• Applications: Flow Cytometry
• Clone: HIP2
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

For Research Use Only.