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CD41b Mouse anti-Human, FITC, Clone: HIP2, BD

Catalog No. BDB555469 Shop All BD Biosciences Products
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Catalog No. BDB555469 Supplier BD Biosciences Supplier No. 555469
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Mouse Monoclonal Antibody

The HIP2 monoclonal antibody specifically binds to CD41b. CD41b/CD41 is encoded by the ITGA2B gene and is also known as Platelet glycoprotein GPIIb and Integrin alpha IIb. CD41 is transmembrane glycoprotein that is post-translationally processed into a disulfide linked α-chain and β-chain. CD41 combines with CD61, otherwise known as Glycoprotein IIIa or β3 integrin, to form the CD41/CD61 (GPIIb/IIIa) complex. This complex is expressed on platelets and megakaryocytes and is involved in platelet activation, aggregation and binding to extracellular matrix proteins. Upon platelet activation, the CD41/CD61 complex can function as a receptor for fribrinogen, fibronectin and von Willebrand factor. In contrast to other CD41b antibodies, HIP2 does not detect anti-ZWa bound to GPIIb/IIIa. This antibody appears to be a weak aggregation inducer.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD41b
Applications Flow Cytometry
Classification Monoclonal
Clone HIP2
Conjugate FITC
Description ITGA2B; CD41; GP2B; GPIIb; GPalpha IIb; Platelet glycoprotein GPIIb
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG3 κ
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For Research Use Only.

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