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CD45 Rat anti-Mouse, Unlabeled, Clone: 30-F11, BD

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BDB553076 0.5 mg
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Catalog No. BDB553076 Supplier BD Biosciences Supplier No. 553076
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Description

Rat Monoclonal Antibody

The 30-F11 antibody reacts with both alloantigens and all isoforms of the CD45 leukocytes common antigen (LCA), also known as Ly-5 or T200, found on hematopoietic stem cells and all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane glycoprotein which is expressed at high levels on the cell-surface, and its presence distinguishes leukocytes from non-hematopoietic cells. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD45
Applications Flow Cytometry
Classification Monoclonal
Clone 30-F11
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Ptprc; CD45R; LCA; Leukocyte common antigen; T200; B220; Ly-5; Lyt-4
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse Thymus or Spleen
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2b κ
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For Research Use Only.

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