CD45 Mouse anti-Human, FITC, Clone: BHPT-1, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112130
DescriptionCD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and maligt, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
|human peripheral blood monocytes from a rheumatoid arthritis patient|
|PBS with 0.2% carrier protein and 0.08% sodium azide|
|B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase; receptor type; c polypeptide; receptor-type tyrosine-protein phosphatase C; HCD45|
|4° C, do not freeze|
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