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CD45 Rat anti-Mouse, V450, Clone: 30-F11, BD
Rat Monoclonal Antibody
Supplier: BD Biosciences 560501
Description
The 30-F11 clone has been reported to react with all isoforms and both alloantigens of CD45, which is found on hematopoietic stem cells and all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane glycoprotein which is expressed at high levels on the cell-surface, and its presence distinguishes leukocytes from non-hematopoietic cells. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family, where the intracellular carboxy-terminal region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated as A, B, and C, respectively). CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction and the CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific.
The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences. It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450 nm. Conjugates with BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates.
Specifications
| CD45 | |
| Monoclonal | |
| 0.2mg/mL | |
| Ptprc; CD45R; LCA; Leukocyte common antigen; T200; B220; Ly-5; Lyt-4 | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| 30-F11 | |
| Violet Fluor 450 (V450) | |
| Aqueous buffered solution containing protein stabilizer, glycerol and ≤0.09% sodium azide. | |
| Mouse Thymus / Spleen | |
| 50 μg | |
| Immunology | |
| Mouse | |
| IgG2b κ |
Safety and Handling
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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