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  6. MilliporeSigma™ anti-CD45R (B220) Red Fluor 710, Clone: RA3-6B2,

MilliporeSigma™ anti-CD45R (B220) Red Fluor 710, Clone: RA3-6B2,

Catalog No. MABF1474MI Shop All MilliporeSigma Products
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MABF1474MI 100 μg
MABF1473MI 25 μg
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Description

Rat Monoclonal Antibody

Specifically detects CD45R (B220) Clone: RA3-6B2 in Human, Mouse samples, and it is validated for Flow Cytometry

The RA3-6B2 antibody reacts with the human and mouse CD45 isoform known as CD45R, or B220, a protein tyrosine phosphatase of 220kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns, all critical for leukocyte function. In mouse, the CD45R/B220 isoform is predominantly found on B cells, at varying levels on all stages from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. It is of note that B220 is not similarly expressed on human B cells, where it appears to be differentiation-specific and therefore expressed on only some B cell subsets. Other forms of CD45 with restricted cellular expression include CD45RA, CD45RB, CD45RO and several others.The RA3-6B2 antibody is one of the most consistently used leukocyte markers for B cells, T cell subsets and NK cell subsets in human and mouse. This antibody has also been reported as cross-reactive with feline CD45R/B220.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD45R (B220)
Applications Flow Cytometry
Classification Monoclonal
Clone RA3-6B2
Conjugate Red Fluor 710
Formulation Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Accession No. P06800
Gene Symbols Ptprc, Ly-5
Host Species Rat
Immunogen Proprietary immunogen
Purification Method Purified by size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Form Purified
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For Research Use Only

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