CD45R Mouse anti-Rat, PE, Clone: HIS24, BD

Catalog No.	Quantity
BDB554881	0.2 mg

Catalog No. BDB554881 Supplier BD Biosciences Supplier No. 554881

Description

Mouse Monoclonal Antibody

The HIS24 antibody reacts with a developmentally regulated form of CD45 found on most B lymphocytes, including developing B cells in the bone marrow and peripheral B cells, but not plasma cells. The level of expression of this CD45R antigen appears to be an indicator of both maturational stages in the B-cell lineage and of functionally distinct B-cell subsets. The HIS24 mAb, in combination with other markers such as TdT and Ig expression, is effective in the identification of B-cell progenitors. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the rat are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.

Specifications

• Antigen: CD45R
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: HIS24
• Concentration: 0.2mg/mL
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Low-Density Cells from AO/G Rat Peyer's Patches
• Purification Method: Affinity Purified
• Quantity: 0.2 mg
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Rat
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2b κ

For Research Use Only.