CD45RB Rat anti-Mouse, PE, Clone: 16A, BD

Catalog No.	Quantity
BDB553101	0.1 mg

Catalog No. BDB553101 Supplier BD Biosciences Supplier No. 553101

Description

Rat Monoclonal Antibody

The 16A antibody reacts with an exon B-dependent epitope of CD45 lycoprotein, which is found at high density on peripheral B cells, T cytotoxic/suppressor cells,subset of T helper cells, and most thymocytes and at low density on macrophages and dendritic cells.The level of CD45RB expressionappears to decrease as T lymphocytes progress from naive to memory cells. In addition, subpopulations of CD4+ T cells which express high and low levels ofD45RB have differentytokine secretion profiles and mediate distinct immunological functions. CD25+D4+ regulatory T (Treg) lymphocytes which control intestinal inflammation and autoimmunity express low levels ofD45RB. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.

Specifications

• Antigen: CD45RB
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 16A
• Concentration: 0.2mg/mL
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Rat
• Immunogen: Cloned Mouse TH2 cell lines
• Purification Method: Affinity Purified
• Quantity: 0.1 mg
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2a κ

For Research Use Only.