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CD45RC Rat anti-Mouse, PE, Clone: DNL-1.9, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 557357

Catalog No. BDB557357


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Description

Description

The DNL-1.9 antibody reacts with an exon C-dependent epitope of CD45 protein which is found at high density on B cells, and at low density on peripheral T cytotoxic/suppressor cells, a subset of peripheral T helper cells, and a very small subset of thymocytes. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOHterminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD45RC
Monoclonal
0.2mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
70Z/3 mouse pre-B cell line
0.1 mg
Immunology
Mouse
IgG2a κ
Flow Cytometry
DNL-1.9
PE
Rat
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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