CD45RO Mouse anti-Human, APC, Clone: UCHL1, BD

Catalog No.	Quantity
BDB340438	100 Tests

Catalog No. BDB340438 Supplier BD Biosciences Supplier No. 340438

Description

Mouse Monoclonal Antibody

CD45RO, a member of the CD45 family that includes CD45, CD45RA, and CD45RB, recognizes a 180-kilodalton (kd) isoform of the leucocyte common antigen (LCA). The CD45 antigen is a protein tyrosine phosphatase. In peripheral blood, the CD45RO antigen is present on approximately 40% of resting peripheral blood T lymphocytes, including the CD4+ and CD8+ subpopulations, as well as on most thymocytes and activated T lymphocytes. It is also expressed on monocytes, macrophages, and granulocytes. The CD45RO antigen is present at low density early in the T-lymphocyte maturation cycle. Upon activation by phytohemagglutinin (PHA) or alloantigen, naive T lymphocytes first acquire CD45RO and then lose CD45RA. When these activated T lymphocytes are rechallenged, the cells that exhibit a secondary response are primarily CD45RO+ , leading to the concept that CD45RO+ cells are a primed population of memory T lymphocytes.

Specifications

• Antigen: CD45RO
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: UCHL1
• Concentration: 50μg/mL
• Conjugate: APC
• Formulation: Phosphate buffered saline with gelatin and 0.1% sodium azide.
• Host Species: Mouse
• Immunogen: Human IL-2-dependent T-cell line
• Quantity: 100 Tests
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.
• Isotype: IgG2a κ

For Research Use Only.