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CD48 Hamster anti-Mouse, APC-Cy7, Clone: HM48-1, BD

Catalog No. BDB561242 Shop All BD Biosciences Products
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BDB561242 50 μg
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Catalog No. BDB561242 Supplier BD Biosciences Supplier No. 561242
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Description

Hamster Monoclonal Antibody

The HM48-1 monoclonal antibody specifically binds to CD48 (previously known as BCM1 in mice, Blast-1 in human, and OX-45 in the rat), a GPI-anchored member of the Ig superfamily. It is widely distributed on leukocytes, but not on non-hematopoietic cells, and its ligands include CD2 (LFA-2) and CD244 (2B4 antigen). The HM48-1 mAb blocks binding of soluble CD2 to CD48-bearing cells, blocks the interaction of CD2 and CD244, inhibits spleen cell proliferative responses to mitogens, augments the proliferative response of spleen cells when cross-linked with anti-CD3e mAbs, and inhibits priming of CTL in vitro. In vivo administration of HM48-1 antibody can prolong survival of cardiac allografts, an effect which is greatly enhanced by the addition of anti-CD2 mAb 12-15. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD48
Applications Flow Cytometry
Classification Monoclonal
Clone HM48-1
Concentration 0.2mg/mL
Conjugate APC-Cyanine7
Description BLAST; BLAST-1; BCM1; HM48-1; MEM-102; Sgp-60; SLAMF2
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Host Species Hamster
Immunogen Mouse T lymphoma MBL-2
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 λ3
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