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Description
The R1-2 antibody reacts with the integrin α 4 chain (CD49d), which is expressed as a heterdimer with either of two β , β 1 or β 7 (also known as β p). The α 4β α 4β 7 also preferentially binds to the mucosal vascular addressin, MAdCAM-1. The R1-2 antibody blocks some α 4 integrin-mediated binding functions. In combination with mAb 9C10 (MFR4.B) (Cat. No. 553313), binding of VLA-4 expressing cells to VCAM-1 can be almost completely inhibited.
Specifications
Specifications
| Antigen | CD49d |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | R1-2 |
| Concentration | 0.2mg/mL |
| Conjugate | Alexa Fluor 647 |
| Description | Integrin α4 chain |
| Formulation | Aqueous buffered solution containing ≤0.09% sodium azide. |
| Host Species | Rat |
| Immunogen | AKR/Cum mouse spontaneous T lymphoma line TK1 |
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