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CD49d Rat anti-Mouse, Biotin, Clone: R1-2, BD

Catalog No. BDB557406 Shop All BD Biosciences Products
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BDB557406 0.1 mg
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Catalog No. BDB557406 Supplier BD Biosciences Supplier No. 557406

Description

Rat Monoclonal Antibody

The R1-2 antibody reacts with the integrin α4 chain (CD49d), which is expressed as a heterdimer with either of two β, β1 or β7 (also known as βp). The α4β1 integrin (VLA-4, CD49d/CD29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes; while the α4β7 integrin (LPAM-1) is expressed on peripheral lymphocytes, but on only a small subset of thymocytes. These integrins mediate a variety of cell-cell and cell-matrix interactions, recognizing the ligands VCAM-1 (CD106) and fibronectin. There is evidence that levels of VLA-4 expression regulate the transendothelial migration of T lymphocytes into inflamed tissues. Integrin α4β7 also preferentially binds to the mucosal vascular addressin, MAdCAM-1. The R1-2 antibody blocks some α4 integrin-mediated binding functions. In combination with mAb 9C10 (MFR4.B) (Mfr. No.553313), binding of VLA-4 expressing cells to VCAM-1 can be almost completely inhibited.

Host Species: Rat
Clone: R1-2
Isotype: IgG2b, κ
Cross Reactivity: Mouse

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD49d
Applications Western Blot
Classification Monoclonal
Clone R1-2
Concentration 0.5mg/mL
Conjugate Biotin
Host Species Rat
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Isotype IgG2b κ
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For Research Use Only.

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