CD49d Rat anti-Mouse, Unlabeled, Clone: 9C10 (MRF4.B), BD

Catalog No.	Quantity
BDB553314	0.5 mg

Catalog No. BDB553314 Supplier BD Biosciences Supplier No. 553314

Description

Rat Monoclonal Antibody

The 9C10 (MFR4.B) antibody reacts with the integrin α;4 chain (CD49d), which is expressed as a heterodimer with either of two β; chains, β;1 or β;7. The α;4β;1 integrin (VLA-4, CD49d/CD29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes; while the α;4β;7 integrin (LPAM-1) is expressed on peripheral lymphocytes, but on only a small subset of thymocytes. These integrins mediate a variety of cell-cell and cell-matrix interactions, recognizing the ligands VCAM-1 (CD106) and fibronectin. Integrin α;4β;7 also preferentially binds to the mucosal vascular addressin, MAdCAM-1. Although the 9C10 (MFR4.B) antibody alone has been reported to have little function-blocking activity, it can augment the inhibitory effects of mAb R1-2 (Cat. No. 553153), resulting in almost complete inhibition of VLA-4 binding to VCAM-1.

Specifications

• Antigen: CD49d
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 9C10 (MRF4.B)
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Description: Integrin α4 chain
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Rat
• Immunogen: Mouse (C57BL/6xA/J)F[1] Fetal Liver Mast MC/9
• Purification Method: Affinity Purified
• Quantity: 0.5 mg
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG2a κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.