CD49d Rat anti-Mouse, PE, Clone: 9C10 (MRF4.B), BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 557420

Catalog No. BDB557420

Description

The 9C10 (MFR4.B) monoclonal antibody specifically binds to the Integrin α 4 chain (CD49d), which is expressed as a heterodimer with either of two β chains, β 1 or β 7. The α 4β 1 integrin (VLA-4, CD49d/CD29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes; while the α β 7 also preferentially binds to the mucosal vascular addressin, MAdCAM-1. Although the 9C10 (MFR4.B) antibody alone has been reported to have little function-blocking activity, it can augment the inhibitory effects of mAb R1-2 (Cat. No. 553153), resulting in almost complete inhibition of VLA-4 binding to VCAM-1.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

• Antigen: CD49d
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: Integrin α4; Itga4; Integrin alpha-4; LPAM alpha; VLA-4 alpha; VLA-4a
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 9C10 (MRF4.B)
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Mouse (C57BL/6xA/J)F[1] Fetal Liver Mast MC/9
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG2a κ

For Research Use Only.