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CD49e Mouse anti-Human, Unlabeled, Clone: 1, BD

Catalog No. BDB610634 Shop All BD Biosciences Products
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BDB610634 150 μg
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Catalog No. BDB610634 Supplier BD Biosciences Supplier No. 610634

Description

Mouse Monoclonal Antibody

Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. They are transmembrane heterodimers composed of α and β subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 α and 9 β subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The integrin α5 subunit is 1049 amino acids with a molecular weight of 150-165kDa. α5 and β1 form a functional fibronectin receptor which is important for vascular development in mice. Both subunits of the fibronectin receptor are heavily glycosylated in their extracellular domains. This modification is essential for proper cell attachment to basal membranes. Integrin α5 has been reported to suppress apoptosis by a Bcl-2 pathway and the C-terminal region is critical for cell motility and cytoskeletal rearrangements.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD49e
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 1
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human Integrin α5 aa. 853-1002
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Isotype IgG2a
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