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CD5 Rat anti-Mouse, PE, Clone: 53-7.3, BD

Catalog No. BDB553022 Shop All BD Biosciences Products
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Catalog No. BDB553022 Supplier BD Biosciences Supplier No. 553022
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Description

Rat Monoclonal Antibody

The 53-7.3 clone has been reported to react with a monomorphic epitope of CD5, a member of the scavenger receptor cysteine-rich protein superfamily and the major ligand of CD72, found on thymocytes, T lymphocytes, thymic NK-T cells, and a subset of B lymphocytes, but not on NK cells or splenic NK-T cells. The level of surface CD5 expression is developmentally regulated in the thymus, starting with low levels on CD4-CD8- thymocytes and increasing as they mature to CD4+CD8+ then CD4+CD8- or CD4-CD8+ thymocytes. Relatively high levels are maintained on peripheral T lymphocytes. The level of CD5 antigen detected on T helper cells has been reported to be somewhat higher than that on T cytotoxic/suppressor and B cells. Few, if any, intestinal intraepithelial lymphocytes bearing the γδ T-cell receptor express CD5. Phenotypic, anatomical, functional, developmental, and pathogenic characteristics of peripheral CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. The frequency of these CD5+ B cells has been reported to show strain-dependent variation. An additional population of CD5+ B lymphocytes resides in the thymus, where it matures from intrathymic B-cell progenitors. It has been proposed that CD5 is a costimulatory molecule which mediates interactions of cells in the immune system and negatively regulates signal transduction mediated by the T-cell receptor and B-cell receptor. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Rat
Clone: 53-7.3
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Mouse Thymus / Spleen

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD5
Applications Flow Cytometry
Classification Monoclonal
Clone 53-7.3
Concentration 0.2mg/mL
Conjugate PE
Description Lymphocyte antigen 1; Cd5; Ly-12; Ly-A; Lyt-1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse Thymus / Spleen
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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