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CD52 Mouse anti-Human, APC-H7, Clone: 4C8, BD

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Catalog No. BDB563611 Supplier BD Biosciences Supplier No. 563611
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Description

Mouse Monoclonal Antibody

The 4C8 monoclonal antibody specifically binds to CD52 which is also known as Cambridge pathology 1 antigen (CAMPATH-1) or Human epididymis-specific protein 5 (HE5). CD52 is a highly N-glycosylated, 25-29 kDa protein whose C-terminus is glycophosphatidylinositol anchored in the membrane. It is highly expressed on the surface of thymocytes and mature lymphocytes but not on their stem cell precursors. It is also expressed on monocytes, dendritic cells, eosinophils and epithelial cells of the epididymis and seminal vesicles but not on neutrophils, plasma cells, platelets or erythrocytes. Although its functional role is not well characterized, the CD52 antigen serves as an exquisitely sensitive target antigen for antibody and complement-mediated lysis of CD52-positive cells. Anti-CD52 antibodies are being used clinically to remove lymphocytes from transplanted bone marrow cell preparations and in the treatment of some malignant diseases.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD52
Applications Flow Cytometry
Classification Monoclonal
Clone 4C8
Conjugate APC-H7
Description Cambridge pathology 1 Ag; CAMPATH-1; Epididymal secretory protein E5; HE5
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human T lymphocytes
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG3 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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