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CD53 Rat anti-Mouse, Alexa Fluor 647, Clone: OX-79, BD

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BDB564931 50 μg
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Catalog No. BDB564931 Supplier BD Biosciences Supplier No. 564931
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Description

Rat Monoclonal Antibody

The OX-79 antibody reacts with CD53, a 35-45-kDa member of the Transmembrane 4-pass protein superfamily (TM4SF). As in the human, mouse peripheral leukocytes express CD53 mRNA and protein, and erythrocytes and nonhematopoietic cells do not. However, the distribution of CD53 in the mouse and rat thymus differs from that in the human. In the mouse, most CD4+8- and major subsets of CD4- CD8- (double-negative) and CD4- CD8+ thymocytes express CD53, while most cortical CD4+ CD8+ (double-positive) thymocytes are CD53-low or CD53-negative. CD53 expression can be induced in double-positive thymocytes by cross-linking of their T-cell receptors with anti-TCR mAb or peptide-pulsed antigen-presenting cells. There is a strong correlation between positive selection of thymocytes and CD53 expression. Its association with CD2 and a tyrosine phosphatase in rat T lymphocytes and with CD19, CD21, HLA-DR, and other TM4SF proteins in human B lymphocytes suggests that CD53 is involved in leukocyte signal transduction.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD53
Applications Flow Cytometry
Classification Monoclonal
Clone OX-79
Concentration 0.2mg/mL
Conjugate Alexa Fluor 647
Description Cd53: Ox-44; Tspan25; Tetraspanin-25
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide
Host Species Rat
Immunogen BAB/14 mouse macrophage cell line RAW 264
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgM κ
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