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CD53 Rat anti-Mouse, Alexa Fluor 647, Clone: OX-79, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564931

Catalog No. BDB564931


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Description

Description

The OX-79 antibody reacts with CD53, a 35-45-kDa member of the Transmembrane 4-pass protein superfamily (TM4SF). As in the human, mouse peripheral leukocytes express CD53 mRNA and protein, and erythrocytes and nonhematopoietic cells do not. However, the distribution of CD53 in the mouse and rat thymus differs from that in the human. In the mouse, most CD4+8- and major subsets of CD4- CD8- (double-negative) and CD4- CD8+ thymocytes express CD53, while most cortical CD4+ CD8+ (double-positive) thymocytes are CD53-low or CD53-negative. CD53 expression can be induced in double-positive thymocytes by cross-linking of their T-cell receptors with anti-TCR mAb or peptide-pulsed antigen-presenting cells. There is a strong correlation between positive selection of thymocytes and CD53 expression. Its association with CD2 and a tyrosine phosphatase in rat T lymphocytes and with CD19, CD21, HLA-DR, and other TM4SF proteins in human B lymphocytes suggests that CD53 is involved in leukocyte signal transduction.

Specifications

Specifications

CD53
OX-79
Alexa Fluor 647
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide
Rat
IgM, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
Cd53: Ox-44; Tspan25; Tetraspanin-25
Affinity purified
BAB/14 mouse macrophage cell line RAW 264
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Documents
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