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CD58 (LFA-3) Mouse anti-Human, PE, Clone: L306.4, BD

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Catalog No. BDB340295 Supplier BD Biosciences Supplier No. 340295
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Description

Mouse Monoclonal Antibody

CD58 (Anti-LFA-3), clone L306.4, is derived from hybridization of mouse Sp2/0 myeloma cells with spleen cells from C3H/HeN mice immunized with Lc-LFA-3 mouse L-cell transfectant.

CD58 (Anti-LFA-3) recognizes a 40 to 65-kdalton cell-surface glycoprotein that is a member of the immunoglobulin superfamily. The CD58 antigen, known as the lymphocyte function–associated antigen-3 (LFA-3), mediates cellular adhesion and participates in signal transduction when it binds to its ligand, the CD2 antigen. Cellular interactions regulated by the CD58/CD2 antigens are involved in the antigen-independent adhesion pathway and cytotoxic T lymphocyte (CTL) activity. The CD58 antigen has two isoforms. One isoform is anchored in the cell membrane by a glycophosphatidyl inositol tail, while the other has a transmembrane hydrophobic segment and a cytoplasmic segment composed of 12 amino acids.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD58
Applications Flow Cytometry
Classification Monoclonal
Clone L306.4
Conjugate PE
Formulation Phosphate buffered saline with gelatin and 0.1% sodium azide.
Host Species Mouse
Immunogen Lc-LFA-3 mouse L-cell transfectant
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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