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CD58 Mouse anti-Human, PE, Clone: 1C3, BD

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Catalog No. BDB555921 Supplier BD Biosciences Supplier No. 555921
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Description

Mouse Monoclonal Antibody

The 1C3 (AICD58.6) monoclonal antibody specifically binds to CD58. CD58 is a a 60-70 kDa glycoprotein member of the immunoglobulin superfamily. CD58, also referred to as the lymphocyte function-associated antigen-3 (LFA-3), has a wide tissue distribution, being expressed on both hematopoietic and non-hematopoietic cells, including endothelial cells and fibroblasts. There are two isoforms of CD58: a glycosylphosphatidylinositol (GPI)-linked form and a transmembrane form. Both isoforms may be expressed on the same cell type. Erythrocytes, however, only express the GPI-linked isoform. CD58 interacts with CD2 during cell adhesion. This binding can enhance antigen-specific T-cell activation. This interaction can also play a role in cell-mediated cytotoxicity.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD58
Applications Flow Cytometry
Classification Monoclonal
Clone 1C3
Conjugate PE
Description LFA-3; LFA3; Lymphocyte function-associated antigen 3; Ag3
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant Human CD58
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Canine, Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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