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CD61 Hamster anti-Mouse, NA/LE, Unlabeled, Clone: 2C9.G2, BD

Catalog No. BDB553343 Shop All BD Biosciences Products
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BDB553343 0.5 mg
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Catalog No. BDB553343 Supplier BD Biosciences Supplier No. 553343
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Description

Hamster Monoclonal Antibody

The 2C9.G2 antibody reacts with the integrin β;3 chain (CD61), which associates with the integrin α;v chain (CD51) to form the vitronectin receptor and with the α;IIb chain (CD41) to form the gpIIb/IIIa complex. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is also mediated by the binding of α;vβ;3 integrin or vitronectin receptor to CD31 (PECAM-1). In addition, interaction of the α;vβ;3 integrin with its ligands regulates the L-type Ca2+ channel in vascular smooth muscle cells, possibly mediating vasodilatory responses to injury. Soluble and insoluble 2C9.G2 mAb mimics the effect of the natural ligands in smooth muscle cells from rat cremaster arterioles. Furthermore, osteopontin, also named Eta-1, is a cytokine that binds to α;vβ;3. CD61 is expressed on platelets, activated T lymphocytes, polymorphonuclear granulocytes, and blastocysts. Cross-reactivity of mAb 2C9.G2 to rat mast cells and platelets has been observed by flow cytometric analysis. mAb 2C9.G2 has been demonstrated to block binding of rat and mouse cells to fibronectin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD61
Applications Flow Cytometry
Classification Monoclonal
Clone 2C9.G2
Concentration 1.0mg/mL
Conjugate Unconjugated
Description Integrin β3 chain
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Hamster
Immunogen Mouse T-cell Hybridoma 2B4 Vitronectin Receptor
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse, Rat
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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For Research Use Only.

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