CD61 Hamster anti-Mouse, Unlabeled, Clone: 2C9.G2, BD

Hamster Monoclonal Antibody

Supplier:  BD Biosciences 550541

Catalog No. BDB550541

Description

The 2C9.G2 antibody reacts with the integrin β;3 chain (CD61), which associates with the integrin α;v chain (CD51) to form the vitronectin receptor and with the α;IIb chain (CD41) to form the gpIIb/IIIa complex. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is also mediated by the binding of α;vβ;3 integrin or vitronectin receptor to CD31 (PECAM-1). In addition, interaction of the α;vβ;3 integrin with its ligands regulates the L-type Ca2+ channel in vascular smooth muscle cells, possibly mediating vasodilatory responses to injury. Soluble and insoluble 2C9.G2 mAb mimics the effect of the natural ligands in smooth muscle cells from rat cremaster arterioles. Furthermore, osteopontin, also named Eta-1, is a cytokine that binds to α;vβ;3. CD61 is expressed on platelets, activated T lymphocytes, polymorphonuclear granulocytes, and blastocysts. Cross-reactivity of mAb 2C9.G2 to rat mast cells and platelets has been observed by flow cytometric analysis. mAb 2C9.G2 has been demonstrated to block binding of rat and mouse cells to fibronectin.

Specifications

• Antigen: CD61
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: Integrin β3 chain
• Host Species: Hamster
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: 2C9.G2
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
• Immunogen: Mouse T-cell Hybridoma 2B4 Vitronectin Receptor
• Quantity: 1 mL
• Research Discipline: Immunology
• Target Species: Mouse, Rat
• Isotype: IgG1 κ

For Research Use Only.