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CD62E Rat anti-Mouse, Unlabeled, Clone: 10E9.6, BD

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BDB550290 1 mL
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Catalog No. BDB550290 Supplier BD Biosciences Supplier No. 550290
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Description

Rat Monoclonal Antibody

The 10E9.6 antibody reacts with the 97-110kDa cell surface glycoprotein E-selectin (CD62E), also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1), which is expressed on endotoxin- or cytokine-stimulated mouse endothelial cells. A suspension of TNFα stimulated mouse brain capillary endothelioma cells, from the cell line bEnd.3, was used as the immunogen. The epitope recognized by mAb 10E9.6 has been mapped to the first and/or second complement regulatory protein repeat domains of E-selectin. The 10E9.6 antibody has been reported to block binding of a monocyte cell line to E-selectin in vitro and to block neutrophil migration in BALB/c, but not C57BL/6 mice. It has no effect on leukocyte rolling in TNFα-treated mouse venules or on in vitro adhesion of myeloid cells to E-selectin. Studies have demonstrated that Cutaneous Lymphocyte Antigen (CLA), recognized by mAb HECA-452 (Cat. no. 555946), may be a ligand for CD62E. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD62E
Applications Flow Cytometry
Classification Monoclonal
Clone 10E9.6
Concentration 125μg/mL
Conjugate Unconjugated
Description E-selectin, ELAM-1
Formulation Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse brain capillary endothelioma bEnd.3 (TNFα-stimulated) Cell Line
Purification Method Affinity Purified
Quantity 1 mL
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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