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CD62E Mouse anti-Human, Brilliant Violet 421, Clone: 68-5H11, BD

Catalog No. BDB563360 Shop All BD Biosciences Products
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BDB563360 100 Tests
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Catalog No. BDB563360 Supplier BD Biosciences Supplier No. 563360
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Description

Mouse Monoclonal Antibody

The 68-5H11 monoclonal antibody specifically binds to CD62E. This adhesion molecule is a 97-115 kDa type I transmembrane glycoprotein that is encoded by the SELE gene. CD62E is also known as E-selectin, Endothelial-leukocyte adhesion molecule-1 (ELAM-1), and Leukocyte endothelial cell adhesion molecule 2 (LECAM-2). CD62E is minimally expressed by unstimulated endothelium. Activated endothelial cells upregulate surface CD62E expression in response to various activators including inflammatory cytokines such as Interleukin-1 and Tumor Necrosis Factor. CD62E plays a role in leucocyte extravasation by promoting leucocyte rolling on activated endothelial cells during inflammation. CD62E may also play a role in the metastasis of certain tumor cells. The adhesion between endothelial CD62E molecules and a carbohydrate ligand on neutrophils is inhibited by the mAb 68-5H11.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD62E
Applications Flow Cytometry
Classification Monoclonal
Clone 68-5H11
Conjugate Brilliant Violet 421
Description SELE; E-selectin; Selectin E; ELAM; ELAM1; ESEL; LECAM2
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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