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Description
Reacts with a 76-95kDa glycoprotein referred to as L-selectin or LECAM-1. CD62L is expressed on neutrophils, monocytes, T- and B-lymphocyte subsets and NK cells. Dreg-56 antibody recognizes the same antigen as LAM-1, and specifically inhibits >90% of binding of human lymphocytes to high endothelial venules (HEV) in frozen sections of peripheral, but not mucosal lymphoid tissue. It thus defines L-selectin as a human lymphocyte homing receptor for peripheral lymph node HEV. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
Specifications
Specifications
| Antigen | CD62L |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | DREG 56 |
| Concentration | 1.0mg/mL |
| Conjugate | Unconjugated |
| Description | SELL; L-selectin; LSEL; LAM-1; LECAM-1; LEU8; LNHR; MEL-14; PLNHR; TQ-1 |
| Formulation | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay. |
| Host Species | Mouse |
| Immunogen | Supernatant from PMA-activated Human Peripheral Blood Leukocytes |
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