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CD64 Mouse anti-Human, Brilliant Violet 421, Clone: 10.1, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 562872

Catalog No. BDB562872


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Description

Description

The 10.1 monoclonal antibody specifically binds to CD64, a 72 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcγRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRγ homodimer to form the functional high affinity FcγRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antigen presentation, antibody-dependent cellular toxicity, cytokine release and superoxide generation.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon™ BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon™ BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue™ conjugates.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD64
Monoclonal
Brilliant Violet 421
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Human Rheumatoid synovial fluid cells and fibronectin-purified monocytes
50 Tests
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
10.1
FCGR1; FcRI; Fc-gamma RI; IgG Fc Receptor I; High affinity IgG FcR1
Mouse
Affinity Purified
RUO
Human
IgG1 κ
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