CD64 Mouse anti-Human, Brilliant Violet 510, Clone: 10.1, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563459
The 10.1 monoclonal antibody specifically binds to CD64, a 72 kDa type I transmembrane glycoprotein that is a high affinity receptor for human IgG (FcγRI), especially the IgG1 and IgG3 subclasses. CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. CD64 associates with a signaling FcRγ homodimer to form the functional high affinity FcγRI complex. CD64 functions in both innate and adaptive immune responses and mediates endocytosis, phagocytosis, antigen presentation, antibody-dependent cellular toxicity, cytokine release and superoxide generation.
The antibody was conjugated to BD Horizon BV510 which is part of the BD Horizon Brilliant Violet family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser
|FCGR1; FcRI; Fc-gamma RI; IgG Fc Receptor I; High affinity IgG FcR1|
|Human Rheumatoid synovial fluid cells and fibronectin-purified monocytes|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Brilliant Violet 510|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
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