CD70 Rat anti-Mouse, APC, Clone: FR70, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 563634
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33-kDa type-II transmembrane glycoprotein belonging to the TNF/NGF superfamily. CD70 is the ligand for CD27 and is expressed primarily on activated B cells. CD70 expression can be induced by activation of splenocytes with lipopolysaccharide and stimulatory antibodies specific for IgM, CD40 or both. mRNA coding for CD70 is transiently expressed after Concanavalin A stimulation of splenocytes or thymocytes. CD70 has been observed to be expressed on dendritic cells of Leishmania major-infected mice. The CD27-CD70 interaction delivers costimulatory signals to T cells and NK cells. It has been reported that FR70 antibody blocks binding of mCD27-Ig fusion protein to mouse Cd70-transfected cells and inhibits some in vitro T-cell- and NK-cell-dependent responses.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|CD27 ligand; CD27l, CD27LG; Tnfsf7; Ki-24 Antigen|
|BALB/c mouse B lymphoma A20.2J|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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