CD70 Rat anti-Mouse, APC, Clone: FR70, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 563634

Catalog No. BDB563634

Description

The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33-kDa type-II transmembrane glycoprotein belonging to the TNF/NGF superfamily. CD70 is the ligand for CD27 and is expressed primarily on activated B cells. CD70 expression can be induced by activation of splenocytes with lipopolysaccharide and stimulatory antibodies specific for IgM, CD40 or both. mRNA coding for CD70 is transiently expressed after Concanavalin A stimulation of splenocytes or thymocytes. CD70 has been observed to be expressed on dendritic cells of Leishmania major-infected mice. The CD27-CD70 interaction delivers costimulatory signals to T cells and NK cells. It has been reported that FR70 antibody blocks binding of mCD27-Ig fusion protein to mouse Cd70-transfected cells and inhibits some in vitro T-cell- and NK-cell-dependent responses.

Specifications

• Antigen: CD70
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: CD27 ligand; CD27l, CD27LG; Tnfsf7; Ki-24 Antigen
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG2b κ

• Applications: Flow Cytometry
• Clone: FR70
• Conjugate: APC
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: BALB/c mouse B lymphoma A20.2J
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.