CD73 Mouse anti-Human, BB515, Clone: AD2, BD

Catalog No.	Quantity
BDB565110	100 Tests

Catalog No. BDB565110 Supplier BD Biosciences Supplier No. 565110

Description

Mouse Monoclonal Antibody

The AD2 monoclonal antibody specifically binds to ecto-5’-nucleotidase, a 70 kDa, glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 is expressed on subsets of T and B lymphocytes, follicular dendritic cells, epithelial cells, endothelial cells and mesenchymal stem cells. Its expression on lymphocytes increases during T and B cell development. CD73 has enzymatic activity and catalyzes the dephosphorylation of adenosine monophosphate (AMP) converting it to adenosine. It has been suggested that CD73 can mediate costimulatory signals in T cell activation and adhesion of lymphocytes to endothelium.

The antibody was conjugated to BD Horizon BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (e.g. 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.

Specifications

• Antigen: CD73
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: AD2
• Conjugate: Brilliant Blue 515 (BB515)
• Description: NT5E; 5' nucleotidase; 5'-NT; E5NT; Ecto-5'-nucleotidase; eN; eNT; NT; NT5
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide
• Host Species: Mouse
• Immunogen: Pre-B leukemia cell line
• Purification Method: Affinity Purified
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov