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CD8 Mouse anti-Human, APC-H7, Clone: SK1, BD

Catalog No. BDB560179 Shop All BD Biosciences Products
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Catalog No. BDB560179 Supplier BD Biosciences Supplier No. 560179
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Description

Mouse Monoclonal Antibody

CD8 recognizes the 32kDa a-subunit of a disulfide-linked bimolecular complex. The majority of peripheral blood CD8+ T lymphocytes express an a/b heterodimer (Mr 32, 30kDa), while CD8+CD16+ natural killer (NK) lymphocytes and CD8+ T-cell receptor (TCR)-γ/δ+ lymphocytes express a/a homodimer (Mr 30kDa). CD8+TCR-α/β+ lymphocytes can express either an α/α homodimer or α/β heterodimer. The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules resulting in increased adhesion between the CD8+ T lymphocytes and target cells. Binding of the CD8 antigen is coupled to a protein tyrosine kinase p56lck. The CD8:p56lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.

Host Species: Mouse
Clone: SK1
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human Peripheral Blood T Cells

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD8
Applications Flow Cytometry
Classification Monoclonal
Clone SK1
Conjugate APC-H7
Description CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32
Formulation Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Peripheral Blood T Cells
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Baboon, Cynomolgus, Human, Rhesus Monkey
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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