CD8 Mouse anti-Human, Clone: MEM-87, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119293
The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
|Leucocytes from a patient suffering from a LGL type leukaemia.|
|Flow Cytometry, Immunoprecipitation|
|PBS with 15mM sodium azide; pH 7.4|
|CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta|
|4° C, do not freeze|
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