CD8 Mouse anti-Human, Mouse, Rat, Clone: RIV11, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA17632
MA1-7632 detects CD8 from human, rat and mouse samples. MA1-7632 has been successfully used in ELISA, flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections) procedures. The MA1-7632 immunogen is a CD8 protein.CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
|PBS with 0.01% sodium azide; pH 7.2|
|P01732, P10966, P01731, P05541, P07725|
|CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta|
|4°C or -80°C if preferred|
|12525, 24930, 24931, 925, 926|
|ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation|
|Human, Mouse, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok