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MilliporeSigma™ anti-CD80 APC, Clone: 16-10A1,

Catalog No. MABF1554MI Shop All MilliporeSigma Products
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MABF1554MI 25 μg
MABF1555MI 100 μg
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Description

Armenian Hamster Monoclonal Antibody

Specifically detects CD80 Clone: 16-10A1 in Mouse samples, and it is validated for Flow Cytometry

The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD80
Applications Flow Cytometry
Classification Monoclonal
Clone 16-10A1
Conjugate APC
Formulation Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Accession No. Q00609
Gene Symbols Cd80, B7
Host Species Armenian Hamster
Immunogen Proprietary immunogen
Purification Method Purified by size-exclusion chromatography
Quantity 25 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage 2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Form Purified
Isotype IgG
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For Research Use Only

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