CD81 Hamster anti-Mouse/Rat, Biotin, Clone: EAT2, BD

Hamster Monoclonal Antibody

Supplier:  BD Biosciences 559518

Catalog No. BDB559518

Description

The Eat2 antibody reacts with CD81, a 26kDa nonglycosylated member of the transmembrane 4 integral membrane protein superfamily, expressed by many types of cells. For example, CD81 participates with CD19 and CD21 in the signal transduction complex associated with the B-cell receptor on human B lymphocytes and with the CD4 and CD8 co-receptors on human thymocytes and T lymphocytes. In mouse fetal thymic organ culture, interactions of immature thymocytes with CD81 expressed by thymic stromal cells are required to induce development of T cells with αβ T-cell receptors. Furthermore, CD81 has been shown to play a role in the regulation of rat mastcell degranulation. Despite its important roles in the immune response and wide tissue distribution, CD81-deficient mice are born without obvious developmental abnormalities. However, these mice have abnormal immune responses, and impaired fertility. Eat2 mAb cross-reacts with the rat CD81 antigen. Eat2 mAb was reported cross-reacting with the rat CD81 antigen.

Flow Cytometry

Specifications

• Antigen: CD81
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: TAPA-1; Tspan28; Tapa1; Tapa-1; Target of the antiproliferative antibody 1;
• Host Species: Hamster
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: EAT2
• Conjugate: Biotin
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: CD81+ mouse B lymphoma 38C13
• Quantity: 0.5 mg
• Research Discipline: Immunology
• Target Species: Mouse, Rat
• Isotype: IgG1 κ