CD86 Mouse anti-Human, Biotin, Clone: IT2.2, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 555664

Catalog No. BDB555664

Description

IT2.2 recognizes a 75kDa cell surface protein, CD86 (B70/B7-2), expressed primarily on monocytes and activated B cells including lymphoid cells in germinal centers and Epstein-Barr virus transformed B-cell lines. CD86 is the second ligand for CD28 and CTLA-4 and may play an important role in costimulation of T cells in primary immune response. Competitive binding assays demonstrate that, while both IT2.2 and FUN-1 (anti-CD86) recognize the same molecule, they react with different epitopes. IT2.2 blocks costimulation activity of CD86 in functional studies and blocks binding of human CTLA-4-Ig fusion protein to B70 gene-transfected cells.

Host Species: Mouse
Clone: IT2.2
Isotype: IgG2b, κ
Species Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CD86
• Classification: Monoclonal
• Conjugate: Biotin
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: IT2.2
• Description: B70/B7-2
• Host Species: Mouse
• Quantity: 100 Tests
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG2b κ

For Research Use Only.