CD88 Mouse anti-Human, Unlabeled, Clone: D53-1473, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 550493

Catalog No. BDB550493

Description

Reacts with a 40kDa polypeptide expressed on granulocytes, monocytes and macrophages. CD88 is a G type protein-coupled receptor with seven transmembrane domains. It binds to C5a, the α chain of the complement component C5. C5a is cleaved from C5 during complement activation. The binding of C5a to C5a receptor (C5aR, CD88) on granulocytes leads to various effects including shedding of selectins, upregulation of adhesion molecules, chemotaxis, granule exocytosis and activation of NADPH oxidase. Clone D53-1473 was developed using a known C5aR N-terminal extracellular hydrophilic region (a.a. 1-31) peptide as immunogen. This antibody is useful in inflammation and chemotaxis research. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: D53-1473
Isotype: IgG1 κ
Species Reactivity: Human

Flow Cytometry, Immunofluorescence

Specifications

• Antigen: CD88
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: C5a Receptor
• Host Species: Mouse
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: D53-1473
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.