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CD8a Mouse anti-Pig, FITC, Clone: 76-2-11, BD

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Description

Mouse Monoclonal Antibody

The 76-2-11 (also known as clone PT8) antibody reacts with an epitope on the CD8α chain, a 35kDa antigen expressed on thymocytes, peripheral T lymphocytes, and NK cells. The CD8 molecule can exist as a 70kDa homodimer, composed of α chains, or heterodimer, composed of an α and β chain. Cells which express the CD8αα homodimer display dimmer staining with mAb 76-2-11 than CDαβ-expressing cells. The 76-2-11 mAb does not cross-react with human or bovine cells. Two peripheral CD8+ T-cell populations can be distinguished in the pig: CD8-bright CD4- CTL effectors/precursors and CD8-dull CD4+ T-helper lymphocytes. Pig NK cells express CD8 (dull staining), CD2, MHC class II, LFA-1, and asialo-GM1, but not CD3, CD4, CD5, or CD6. mAb 76-2-11 has been reported to partially inhibit in vitro cytotoxic activity of PBL to allogeneic leukocytes, but not NK-cell-mediated lysis, and to deplete CD8+ T cells in vivo. This clone was clustered as anti-CD8a at the First International Swine CD workshop.

Host Species: Mouse
Clone: 76-2-11
Isotype: IgG2a κ
Species Reactivity: Porcine
Immunogen: dd miniature swine thymocytes

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD8a
Applications Flow Cytometry
Classification Monoclonal
Clone 76-2-11
Concentration 0.5mg/mL
Conjugate FITC
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen dd miniature swine thymocytes
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Pig
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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