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CD8a Mouse anti-Rat, PerCP, Clone: OX-8, BD

Catalog No. BDB558824 Shop All BD Biosciences Products
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Catalog No. BDB558824 Supplier BD Biosciences Supplier No. 558824
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Description

Mouse Monoclonal Antibody

The OX-8 antibody reacts with the hinge-like membrane-proximal domain of the 32kDa α chain of the CD8 differentiation antigen. A truncated CD8 α′ isoform has not been detected in the rat. The CD8 α and β chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). Intestinal intrapithelial lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most NK cells express CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to thymus-derived T lymphocytes. OX-8 antibody does not react with resting CD4+ T helper cells. CD8 is an antigen coreceptor on the T-cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Ick. Macrophages have also been reported to express CD8 α and β chains, which are involved in signal transduction. Soluble OX-8 mAb partially blocks in vitro MLR and CTL activity. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: OX-8
Isotype: IgG1 κ
Species Reactivity: Rt
Immunogen: High-molecular-weight rat thymocyte glycoproteins

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD8a
Applications Flow Cytometry
Classification Monoclonal
Clone OX-8
Concentration 0.2mg/mL
Conjugate PerCP
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen High-molecular-weight rat thymocyte glycoproteins
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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