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MilliporeSigma™ anti-CD8a PerCP-Cy5.5, Clone: 53-6.7,

Rat Monoclonal Antibody

$153.50 - $261.00

Specifications

Antigen CD8a
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Format Purified
Formulation Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MABF1547MI
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MilliporeSigma™
MABF1547
25μg
Each for $153.50
Add to cart
 
MABF1548MI
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MilliporeSigma™
MABF1548
100μg
Each for $261.00
Add to cart
 
Description

Description

Specifically detects CD8a Clone: 53-6.7 in Mouse samples, and it is validated for Flow Cytometry

The 53-6.7 antibody reacts with the 32-34kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.
Specifications

Specifications

CD8a
Monoclonal
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Flow Cytometry
IgG2a, κ
P01731
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
Inflammation, Immunology
Primary
Purified
53-6.7
Rat
Proprietary immunogen
CD8a
RUO
Purified by size-exclusion chromatography
SDS
Product Certifications

For Research Use Only

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