CD8b Mouse anti-Human, APC, Clone: 2ST8.5H7, BD

Catalog No.	Quantity
BDB641058	100 Tests

Catalog No. BDB641058 Supplier BD Biosciences Supplier No. 641058

Description

Mouse Monoclonal Antibody

⁺ suppressor T-cell clone termed 20a6.

The CD8β antibody recognizes an epitope formed by the combination of CD8 alpha and beta chains. The majority of peripheral blood CD8⁺ T lymphocytes expresses an α/β heterodimer (32, 30 kilodaltons (kDa)), while CD8⁺CD16⁺ natural killer (NK) lymphocytes and CD8⁺ T-cell receptor (TCR)-γ/δ NK cells. The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules, resulting in increased adhesion between the CD8⁺ T lymphocytes and target cells. Binding of the CD8 antigen to class I MHC molecules enhances the activation of resting T lymphocytes. The CD8 antigen is coupled to a protein tyrosine kinase, p56^lck. The CD8:p56^lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.

Specifications

• Antigen: CD8b
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 2ST8.5H7
• Concentration: 25μg/mL
• Conjugate: APC
• Formulation: Phosphate buffered saline with gelatin and 0.1% sodium azide.
• Host Species: Mouse
• Immunogen: CD8
• Purification Method: Affinity Purified
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed.
• Isotype: IgG2a κ